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Single cell multiplex biotechnology lab

bioimaging, biodynamics and biocomputation

Coskun Lab at Georgia Tech BME & Emory

Imaging one cell at a time for spatial context

We are multi-disciplinary researchers interested in photons, ions, and electrons and their interactions with cells. Using large-scale experiments and computational analysis, we address fundamental challenges in infections, cancers, and immunology. In a nutshell, we create image-based ‘omic technologies to reveal spatial nature of biological systems. We benefit from enabler tools: Engineered nanomaterials, barcoded biochemical reagents, advanced algorithms and automated microfludics. Topical interests include Spatial Biology, Liquid Biopsy, and Global Oncology. Our lab is currently funded by NIH K25, BWF CASI and MHCRI

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NEWS

[August 15, 2019] Lab starts at Georgia Tech & Emory Medicine

We are hiring prospective students, postdoctoral scholars, and technical assistants.

Prospective candidates should email their resume and interests to "coskunlaboratory@gmail.com" and "coskun@stanford.edu"

Technologies for Spatial Bioengineering

Image-based interrogation of molecular distributions have been widely used in biology, but with limited number of markers due to the color limitations of the microscopes. However, cellular decisions are guided by interactions of at least 20,000 protein-coding genes and their downstream and upstream protein factors. This large number of molecular maps has been studied by single-cell RNA sequencing or mass spectrometer, but the spatial details of positions of cells in complex tissues have been lost during the measurements.

Our research team aims to bridge this gap by developing multiplex image barcoding to visualize and quantify many transcripts, proteins, and metabolites at the molecular scale.

Our team develops purpose-driven multiplex bioimaging technologies that can visualize two/three-dimensional (2D/3D) spatial heterogeneity of biological systems at the single cell and subcellular level.