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Single Cell Biotechnology Laboratory
at Georgia Tech and Emory University
PI: Ahmet F. Coskun, Ph.D.
Bernie Marcus Early-Career Professor

We are hiring prospective students, postdoctoral scholars, and technical assistants.
Prospective candidates should email their resume and interests 

We study spatial biology in health and disease. Our research lies at the nexus of multiplex bioimaging, microfluidic biodynamics, and big data biocomputation. Using high-dimensional nanoscale imaging datasets, we address fundamental challenges in immuno-engineering, cancers, and pediatric diseases. Our lab pursues a transformative multi-omics technology to integrate spatially resolved epigenetics and spatial genomics, proteomics, and metabolomics, all in the same platform. We uniquely benefit from super-resolution microscopy, imaging mass spectrometry, combinatorial molecular barcoding, and machine learning to enhance the information capacity of our cellular data. Variability of single cell images can be used to understand differences in therapeutic responses, as well as satisfy our curiosity on understanding how cells are spatially organized in nature.

  • Spatially resolved 3D metabolomic profiling in tissues, Science Advances (2021) [Link]
    Shambavi Ganesh, Thomas Hu, Eric Woods, Mayar Allam, Shuangyi Cai, Walter Henderson, and Ahmet F. Coskun

Spatially visualized single-cell pathology of highly multiplexed protein profiles in health and disease, Communications Biology  (2021) [Link]
Mayar Allam, Thomas Hu, Shuangyi Cai, Krishman Laxminarayanan, Robert B. Hughley, and Ahmet F. Coskun

Virtual and augmented reality for biomedical applications, Cell Reports Medicine  (2021) [Link]
Mythreye Venkatesan,  Harini Mohan, Justin Ryan, Christian Schuerch, Garry Nolan, David Frakes, and Ahmet F. Coskun

Spatially variant immune infiltration scoring in human cancer tissues, Npj Precision Oncology  (2022) [Link]
Mayar Allam ,Thomas Hu ,Jeongjin Lee , Jeffrey Aldrich , Sunil Badve , Yesim Polar , Manali Bhave , Suresh Ramalingam ,  Frank Schneider, and  Ahmet F. Coskun

Multiplexed protein profiling reveals spatial subcellular signaling networks, iScience (2022) [Link]
Shuangyi Cai, Thomas Hu, Mythreye Venkatesan, Mayar Allam, Suresh Ramalingam, Shi-Yong Sun, and  Ahmet F. Coskun

  • Extracellular Matrix in Synthetic Hydrogel-based Prostate Cancer Organoids Regulate Therapeutic Response to EZH2 and DRD2 inhibitors, Advanced Materials (2021)[Link]
    Coskun Lab and Singh Lab at Georgia Tech & Emory University [FUNDED BY WELCOME LEAP]

Single-cell analysis reveals effective siRNA delivery in brain tumors with microbubble-enhanced ultrasound and cationic nanoparticles, Science Advances  (2021) [Link]
Coskun Lab and Arvanitis Lab at Georgia Tech & Emory University

email
ahmet.coskun@bme.gatech.edu

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phone
404.894.2000

address
Parker H. Petit Institute for Bioengineering and Biosciences at Georgia Tech
315 Ferst Dr NW, Atlanta, GA 30332