How do cells decide to change from stem cells to specific immune cells?We use in vitro cultures and in vivo mouse models to study cell fate selection during development from stem cells
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Would combination of checkpoint blockade enhance therapeutic outcome?
We study spatial changes in receptor polarization in tumor microenvironment
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Would epigenetic modulation make an immune cell more active toward cancers?
We explore metabolic and functional state of T-cells and B-cells as a function of epigenetic perturbations - spatial intracellular changes are used as optimization strategy.
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