AWARD

[11/2022] Dr Coskun received a 2023 BMES-CMBE Rising Star Junior Faculty Award

The BMES Cellular and Molecular Bioengineering Special Interest Group brings together researchers with diverse scientific and clinical interests with a common goal of understanding and engineering molecules, cells, their interactions, and microenvironments in the pursuit of controlling biological processes and improving the practice of medicine. To maintain its multidisciplinary character and central research focus, the CMBE SIG is committed to supporting new investigators within the field. Towards this goal, the “Rising Star” award has been given to a select group of exceptional junior principal investigators each year. Awardees provide a podium presentation in a special session at the annual conference.

For more information:  https://www.bmes.org/rising-stars

FUNDING

[9/2022] Our lab received an Regenerative Engineering and Medicine research grant

Excited to receive a seed grant from the Regenerative Engineering and Medicine (REM) research center for our collaborative work with Edwin Horwitz (Emory) on "spatial transcriptomics of stem cells used for GVHD treatments".

For more information:  REM Center Awards 2022 Seed Grants to Five Interdisciplinary Teams

FUNDING

[8/2022] Our lab contributes to an NIH R01 on Cancer Disparity in African Americans

Diffuse large B-cell lymphoma (DLBCL) is a fast-growing, aggressive, and all-too-common form of non-Hodgkin lymphoma. And even though white people in the U.S. are more likely to develop it, people of African descent are diagnosed 10 years earlier, on average, and their 5-year survival outcome is much worse. Using advanced sequencing and spatial-omics analysis, together with novel patient-derived organoids developed in Singh’s lab, the researchers plan to study the interactions between patient-level factors, tumor genetics, and the tumor microenvironment as features that contribute to racial disparities in diagnosis, survival, and treatment.

For more information:  Georgia Tech-Emory Collaboration on Cancer Disparity in African Americans Gets NIH Boost

FUNDING

[7/2022] Our lab received an American Lung Association Innovation Award

This award will support promising independent investigators who are leveraging their existing body of work to conduct basic science, behavioral, clinical, or translational research for lung health. Since 1915, the American Lung Association Research Team has made significant contributions to the fight against lung disease by revolutionizing treatment and unlocking secrets of the body's immune system. We have funded breakthroughs in the fight against tuberculosis, identified genes that cause the development of lung cancer and cystic fibrosis, and developed innovative ways to treat respiratory distress syndrome. The American Lung Association nationwide research program is building on over a century of success as we continue to invest in the brightest, pioneering minds wit immense potential to drive innovation, discover the unknown, and improve the lives of those living with lung disease.

For more information: Innovation Award

STUDENT HOSTING

[7/2022] Hosted Adam Ford, a NSF REU student, in the lab for stem cell projects

Excited to host our Cell Manufacturing Technologies (CMaT) NSF-supported REU student, Adam Ford from the Cell Sheet Tissue Engineering Center at the University of Utah, in our lab. Adam has already contributed to two manuscripts on spatial omics of MSCs for regenerative medicine. The future of single-cell biotech is bright!

For more information: https://cellmanufacturingusa.org/paid-summer-undergraduate-student-research-opportunities

STUDENT AWARD AND FUNDING

[6/2022] Our graduate student received a T32 training support from NIH NIGMS  InQuBATE @ GT

Congrats to our PhD Student Nicholas Zhang (Nicky) for his selection to the Integrative and Quantitative Biosciences Accelerated Training Environment at the InQuBATE @ GT NIGMS T32 training program for his project on single cell spatially resolved translational regulation.

For more information: https://sites.gatech.edu/inqubate/ sites.gatech.edu/inqubate/

TEACHING AWARD

[6/2022] Prof Coskun received the Student Recognition of Excellence in Teaching: Spring Semester 2022 CIOS Honor Roll (BMED 3520)

I am honored to inform you that you are a recipient of the Student Recognition of Excellence in Teaching: 2022 CIOS Spring Roll.  Congratulations!

For more information: BME GATECH NEWS ARTICLE

TEACHING AWARD

[2/2022] Prof Coskun received the Student Recognition of Excellence in Teaching: Class of 1934 CIOS Award (BMED 4783)

I am honored to inform you that you are a recipient of the Student Recognition of Excellence in Teaching: 2021 CIOS Award.  Congratulations! Funds for the award this year have been provided by the Class of 1934 and the Jack and Frances Mundy endowment accounts.

For more information: https://ctl.gatech.edu/faculty/awards/1940
BME GATECH NEWS ARTICLE: Best Teachers at Tech? Students Say Ahmet Coskun, Martin Jacobson

FUNDING

[2/2022] Our lab received an American Cancer Society Institutional Research Grant

The American Cancer Society Institutional Research Grants (ACS-IRG) are designed to support the development of beginning investigators conducting cancer research by providing pilot funds to obtain preliminary results that will enable them to compete successfully for national research grants.

For more information:  https://winshipcancer.emory.edu/research/funding-opportunities/acs-irg-awards.html

FUNDING

[1/2022] Our lab received 3 SEED grants (with other 3 labs) from the M-CELS @ GaTech

Multi-cellular engineered living systems (M-CELS) are purpose-driven living systems with multiple interacting living components. They are engineered for specific goals or functions but take emergence into account during the design process, allowing the final system to emerge through natural and non-natural biological processes.
M-CELS research is intended to provide a fundamental engineering understanding that enables a quantitative approach bridging between single cells and organs or organisms. The field is still developing, so M-CELS as a field of research is still rapidly expanding. Based on current activities dispersed across the Institute, Georgia Tech is well-positioned to lead the field.

For more information:  https://mcels.ibb.gatech.edu/

FUNDING

[12/2021] Our lab's user proposal has been funded by the OAK RIDGE NATIONAL LABORATORY
for spatial metabolomics research in the CENTER FOR NANOPHASE MATERIALS SCIENCES

The Center for Nanophase Materials Sciences (CNMS) at Oak Ridge National Laboratory (ORNL) is soliciting proposals for user-initiated nanoscience research that will make effective use of CNMS facilities and staff expertise. The CNMS nanoscience research program provides users with access to a broad range of capabilities for nanomaterials design, synthesis, characterization, and theory/modeling/simulation and access is provided at no cost to users for research that is in the public domain and intended for publication in the open literature.

For more information:  https://www.ornl.gov/facility/cnms/output/call-user-proposals

STUDENT AWARDS

[12/2021] Jeongjin Lee received the Alfred H. Gibeling Family Research Fund Award

Jeongjin received the Alfred H. Gibeling Family Research Fund Award which provides support of undergraduate research in the Wallace H. Coulter Department of Biomedical Engineering. Distributions from the Fund will be in the award for undergraduate research stipends and/or materials.
This award is in recognition of your proposal entitled “Exploring Stem-like T Cells in Non-Small Cell Lung Cancer using Imaging Mass Cytometry.”

FUNDING

[07/2021] Our lab received a Winship Lung Cancer SPORE pilot grant

The Winship Lung Cancer SPORE Developmental Research Program (DRP) aims to identify new and innovative research opportunities by supporting meritorious proposals that could expand into full research projects in the future, including those of high risk-high reward projects that might otherwise not be funded; to foster collaborative research between investigators; and to enhance translational research in lung cancer by increasing the number of meritorious investigators working on lung cancer.

For more information:  https://winshipcancer.emory.edu/research/funding-opportunities/lung-spore-pilot-grants.html

FUNDING

[05/2021] Our lab and Thomas Hu received a 2021 IEN Facility Seed Grant

The Institute for Electronics and Nanotechnology at Georgia Tech has announced the winners for the 2021 Facility Seed Grants. The primary purpose of this program is to give first- or second-year graduate students in diverse disciplines working on original and un-funded research in micro- and nano-scale projects the opportunity to access the most advanced academic cleanroom space in the Southeast. In addition to accessing the high-level fabrication, lithography, and characterization tools in the labs, the students will have the opportunity to gain proficiency in cleanroom and tool methodology and to use the consultation services provided by research staff members of the IEN.  In addition, the Seed Grant program gives faculty with novel research topics the ability to develop preliminary data in order to pursue follow-up funding sources.

For more information:  rh.gatech.edu/news/644853/2021-2022-georgia-tech-institute-electronics-and-nanotechnology-ien-core-facilities-seed

FUNDING

[04/2021] Wellcome Leap Grant Funds Work to Create Human Immune Responses

A team of researchers from the Georgia Institute of Technology and Emory University has been awarded a multi-million-dollar, multi-year award from Wellcome Leap as part of the nonprofit’s international $50 million Human Organs, Physiology, and Engineering (HOPE) program. This project is performed by a multidisciplinary investigative team that includes Andrés García, executive director of the Petit Institute for Bioengineering and Bioscience at Georgia Tech; Krishnendu Roy, director of the NSF Center for Cell Manufacturing Technologies; Ahmet Coskun, assistant professor in BME; and Jeremy Boss, chair of Emory’s Department of Microbiology and Immunology.

For more information:  www.bme.gatech.edu/bme/wellcome-leap-grant-funds-work-create-human-immune-responses

PROMOTION

[06/2020] Dr. Coskun received "the Bernie Marcus Early-Career Professorship in Therapeutic Cell Characterization and Manufacturing"

This professorship was established in 2019 by Georgia Tech to celebrate pleased to celebrate Bernie Marcus on his 90th birthday by naming an early career professorship in his honor. This Professorship was established to recognize faculty who have recently been recruited to support Georgia Tech’s Center of Marcus Center with invaluable discretionary funding to advance their research efforts and ultimately impact human health. This offer is in recognition of your ongoing and outstanding impactful contributions to the Department of Biomedical Engineering and the profession, nationally and internationally as a leader, scholar and mentor.

For more information: https://provost.gatech.edu/endowed-chairs-and-professorships

TEAM UPDATE

[06/2020] Master's student, Shambavi Ganesh, graduated from the Coskun lab

Shambavi's C-lab productivity score:
5 journal publications (2 first-author)
2 conference proceedings,
all in a year (2019-2020).

We wish her good luck for her future endeavors!

TEAM UPDATE

[07/2020] Congrats to our undergraduate researcher Sam Henderson for winning the "The CNOOC Energy U.S.A.,LLC. US Scholarship"

EDITORIAL

[05/2020] Special Issue "Single Cell Analysis and Spatial Omics for Cell-Based Diagnostics"

Powerful genome-wide technologies have expanded the field of genomics for finding gene regulatory factors. However, these approaches can only provide population average data that combine information from millions of cells. This population heterogeneity can be resolved by analyzing interactions of regulatory elements in single cells. Current single-cell profiling technologies resolve this cellular variability using label-free monitoring, live-cell imaging, microfluidics single-cell assays, and single-molecule nucleic acid detection methods to achieve spatially resolved analysis of genes, proteins, and metabolites. While single-cell methods shed light on cell-based diagnostics, they have been limited to the screening of only a few genes at a time. There is an increasing demand in biology and medicine for single-cell analysis technologies that can both capture spatial data and high-throughput molecular differences of individual cells. To provide solutions to this important need, this Special Issue discusses emerging technologies and computational approaches to define a new field of spatial omics (genomics, proteomics, metabolomics, and multi-omics) in health and disease.
Dr. Ahmet Coskun
Guest Editor

For more information: https://www.mdpi.com/journal/diagnostics/special_issues/Spatial_Omics

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PAPER

[05/2020] Our npj Precision oncology article is now published on spatial omics for cancers

Personalized cancer treatments could improve by combining single-cell proteomic, genomic and metabolic profiles with computational predictive analysis

For more information:
https://bme.gatech.edu/bme/improving-precision-oncology-using-multiplexed-bioimages-and-artificial-intelligence
https://petitinstitute.gatech.edu/news/improving-precision-oncology-using-multiplexed-bioimages-and-artificial-intelligence

SEMINARS

 [05/2020] Co-organizing a Spatial Omics Seminar Series

Dr. Coskun organizes a virtual zoom seminar series together with Dr. Rong Fan (Yale University)

For more information: https://zoom.us/j/5948746137?pwd=OgsrN4xCP5M

For more details spatialomics.net

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EDITORIAL

[02/2020] Joined Editorial Board of Diagnostics Journal.

Dr. Coskun will serve as Editor for Diagnostics journal for broad submissions and special issues.

For more information: https://www.mdpi.com/journal/diagnostics/editors

FUNDING

[01/2020] Cell Manufacturing funded our proposal

Our joint project was funded by @CMaT_ERC in collaboration with Sakis Mantalaris Lab to understand the the heterogeneity of mesenchymal stem cells, through single cell analytical technology, to improve biomanufacturing strategies.

PAPER

[12/2019] The Future of Poster Sessions

Coskun lab presents concept for digital posters for interactive cellular media and bioengineering educationAhmet Coskun has seen the future for the ubiquitous poster session and it is paperless. Coskun, assistant professor in the Wallace H. Coulter Department of Biomedical Engineering (BME) at Georgia Tech and Emory University, instead envisions a more vibrant way to present research to participants at scientific conferences and other gatherings.“Paper posters fail to explain the dynamic properties of our imaging data, so we cannot adequately connect our research with the audience,” says Coskun, who is also a researcher in the Petit Institute for Bioengineering and Bioscience at Tech, where he directs the Single Cell Biotechnology Laboratory. There, an interdisciplinary team of researchers interested in photons, ions, and electrons (and their interactions with cells) combines large-scale experiments and computational analysis to address fundamental challenges in infections, cancers, and immunology to create image-based technologies to reveal the spatial nature of biological systems.
Georgia Tech BME News
Petit Institute News

NEWS

[December, 2019] Mayar, Shuangyi, Mythreye, Shambavi, Zexing and Saurabh joined the lab as graduate researchers. Stay tuned for their exciting projects at GT!

VISION

[10/2019] BioEngineering Media Lab initiated - bioemedialab.org

Bioengineering (BioE) Media Lab started in 2019 at the Biomedical Engineering Department of Georgia Institute of Technology and Emory University. The mission of this interactive studio lab is to integrate emerging digital technologies with cellular imaging and analysis tools for unconventional scientific explorations and innovative educational teaching platforms.The interactive bio-engineering projects will enhance collaboration among interdisciplinary scientists. Digital visualizations will enhance sensitivity and specificity of molecular and cellular analysis in patient samples.The experimental datasets and resources are based on scientific research endeavors in the Coskun Laboratory at Georgia Tech (coskunlab.org).
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PROFILE

[09/2019] Ahmet Coskun Joins Coulter Department as Assistant Professor

The Single Cell Biotechnology Lab aims to study spatial biology in health and disease. Our research lies at the nexus of multiplex bioimaging, microfluidic biodynamics, and big data biocomputation. Using high-dimensional nanoscale imaging datasets, we address fundamental challenges in immuno-engineering, cancers, and pediatric diseases. Our lab pursues a transformative multi-omics technology to integrate spatially resolved epigenetics and spatial genomics, proteomics, and metabolomics, all in the same platform. We uniquely benefit from super-resolution microscopy, imaging mass spectrometry, combinatorial molecular barcoding, and machine learning to enhance the information capacity of our cellular data. Variability of single cell images can be used to understand differences in therapeutic responses, as well as satisfy our curiosity on understanding how cells are spatially organized in nature.
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