EDITORIAL

[05/2020] Special Issue "Single Cell Analysis and Spatial Omics for Cell-Based Diagnostics"

Powerful genome-wide technologies have expanded the field of genomics for finding gene regulatory factors. However, these approaches can only provide population average data that combine information from millions of cells. This population heterogeneity can be resolved by analyzing interactions of regulatory elements in single cells. Current single-cell profiling technologies resolve this cellular variability using label-free monitoring, live-cell imaging, microfluidics single-cell assays, and single-molecule nucleic acid detection methods to achieve spatially resolved analysis of genes, proteins, and metabolites. While single-cell methods shed light on cell-based diagnostics, they have been limited to the screening of only a few genes at a time. There is an increasing demand in biology and medicine for single-cell analysis technologies that can both capture spatial data and high-throughput molecular differences of individual cells. To provide solutions to this important need, this Special Issue discusses emerging technologies and computational approaches to define a new field of spatial omics (genomics, proteomics, metabolomics, and multi-omics) in health and disease.
Dr. Ahmet Coskun
Guest Editor

For more information: https://www.mdpi.com/journal/diagnostics/special_issues/Spatial_Omics

PAPER

[05/2020] Our npj Precision oncology article is now published on spatial omics for cancers

Personalized cancer treatments could improve by combining single-cell proteomic, genomic and metabolic profiles with computational predictive analysis

For more information:
https://bme.gatech.edu/bme/improving-precision-oncology-using-multiplexed-bioimages-and-artificial-intelligence
https://petitinstitute.gatech.edu/news/improving-precision-oncology-using-multiplexed-bioimages-and-artificial-intelligence

SEMINARS

 [05/2020] Co-organizing a Spatial Omics Seminar Series

Dr. Coskun organizes a virtual zoom seminar series together with Dr. Rong Fan (Yale University)

For more information: https://zoom.us/j/5948746137?pwd=OgsrN4xCP5M

For more details spatialomics.net

EDITORIAL

[02/2020] Joined Editorial Board of Diagnostics Journal.

Dr. Coskun will serve as Editor for Diagnostics journal for broad submissions and special issues.

For more information: https://www.mdpi.com/journal/diagnostics/editors

FUNDING

[01/2020] Cell Manufacturing funded our proposal

Our joint project was funded by @CMaT_ERC in collaboration with Sakis Mantalaris Lab to understand the the heterogeneity of mesenchymal stem cells, through single cell analytical technology, to improve biomanufacturing strategies.

PAPER

[12/2019] The Future of Poster Sessions

Coskun lab presents concept for digital posters for interactive cellular media and bioengineering educationAhmet Coskun has seen the future for the ubiquitous poster session and it is paperless. Coskun, assistant professor in the Wallace H. Coulter Department of Biomedical Engineering (BME) at Georgia Tech and Emory University, instead envisions a more vibrant way to present research to participants at scientific conferences and other gatherings.“Paper posters fail to explain the dynamic properties of our imaging data, so we cannot adequately connect our research with the audience,” says Coskun, who is also a researcher in the Petit Institute for Bioengineering and Bioscience at Tech, where he directs the Single Cell Biotechnology Laboratory. There, an interdisciplinary team of researchers interested in photons, ions, and electrons (and their interactions with cells) combines large-scale experiments and computational analysis to address fundamental challenges in infections, cancers, and immunology to create image-based technologies to reveal the spatial nature of biological systems.
Georgia Tech BME News
Petit Institute News

TEAM

[11/2019] Coskun Lab extended to more than a dozen researchers

Our lab is growing. Currently, Coskun lab has about 14 members, comprising graduate and undergraduate students.

VISION

[10/2019] BioEngineering Media Lab initiated - bioemedialab.org

Bioengineering (BioE) Media Lab started in 2019 at the Biomedical Engineering Department of Georgia Institute of Technology and Emory University. The mission of this interactive studio lab is to integrate emerging digital technologies with cellular imaging and analysis tools for unconventional scientific explorations and innovative educational teaching platforms.The interactive bio-engineering projects will enhance collaboration among interdisciplinary scientists. Digital visualizations will enhance sensitivity and specificity of molecular and cellular analysis in patient samples.The experimental datasets and resources are based on scientific research endeavors in the Coskun Laboratory at Georgia Tech (coskunlab.org).
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PROFILE

[09/2019] Ahmet Coskun Joins Coulter Department as Assistant Professor

The Single Cell Biotechnology Lab aims to study spatial biology in health and disease. Our research lies at the nexus of multiplex bioimaging, microfluidic biodynamics, and big data biocomputation. Using high-dimensional nanoscale imaging datasets, we address fundamental challenges in immuno-engineering, cancers, and pediatric diseases. Our lab pursues a transformative multi-omics technology to integrate spatially resolved epigenetics and spatial genomics, proteomics, and metabolomics, all in the same platform. We uniquely benefit from super-resolution microscopy, imaging mass spectrometry, combinatorial molecular barcoding, and machine learning to enhance the information capacity of our cellular data. Variability of single cell images can be used to understand differences in therapeutic responses, as well as satisfy our curiosity on understanding how cells are spatially organized in nature.
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